David W. Grotto, RD, LDN See book keywords and concepts | The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial. Ann Intern Med. 2006 Sep 5;145(5):333-341.
Juan ME et al. Olive fruit extracts inhibit proliferation and induce apoptosis in HT-29 human colon cancer cells. /Nutr. 2006 Oct;136(10):2553-2557.
Lee A, Thurnham DI, Chopra C. Consumption of tomato products with olive oil but not sunflower oil increases the antioxidant activity of plasma. Free Radical Biology & Medicine. 29:1051-1055; 2000.
Owen RW et al. Olives and olive oil in cancer prevention. Eur / Cancer Prev. 2004 Aug;13(4):319-326.
Onions www. | | Whole grain foods and heart disease risk. J Am CollNutr. 2000 Iun;19(3 Suppl):291S-299S.
Jensen MK, Koh-Banerjee P, Hu FB, Franz M, Sampson L, Gronbaek M, Rimm EB. Intakes of whole grains, bran, and germ and the risk of coronary heart disease in men. Am} Clin Nutr. 2004;80(6): 1492-1499.
Johnsen NF, Hausner H, Olsen A, Tetens I, Christensen J, Knudsen KE, Overvad K, Tjonneland A. Intake of whole grains and vegetables determines the plasma entero-lactone concentration of Danish women. J Nutr. 2004 Oct;134(10):2691-2697.
Mamiya T et al. | Joan Liebmann-Smith, Ph. D., and Jacqueline Nardi Egan See book keywords and concepts | Having a fatty middle can signal metabolic syndrome, a cluster of diabetes and heart disease risk factors that includes insulin resistance, high blood pressure, high blood sugar, high triglyceride levels, and low HDL (high-density lipoprotein or "good" cholesterol) levels. Indeed, people who are apple-shaped are three times more likely to suffer a heart attack than those who are pear-shaped—that is, carrying most of their fat in their buttocks. | Wendy Bazilian, DRPH, MA, RD, Steven Pratt, MD, Kathy Matthews See book keywords and concepts | We know that exercisers can reduce heart disease risk as well as risk of diabetes, osteoporosis, colon cancer, and high blood pressure as well as other disease risks. The very good news is that these benefits can be enjoyed with a regular, moderate physical activity such as walking. It's easy to set and achieve goals when you exercise-walk, particularly with the help of a pedometer. In fact, research has demonstrated that walking is the chosen exercise among people who lose weight and subsequently maintain their healthy weight." Your goal on the SlimDown is to walk 30 minutes a day. | Bottom Line Health See book keywords and concepts | | If you have diabetes or metabolic syndrome, you need to know that they are reversible, and you can improve your heart disease risk profile [even] without normalizing your body weight," Roberts says.
DIET AND EXERCISE ARE KEY
Both Roberts and Nori say the combination of diet and exercise is the reason for these dramatic changes. Neither measure alone is as powerful as the two together. And both say you must maintain the changes in order to sustain the health benefits.
"People have the power within themselves to make a difference. | Steven V. Joyal See book keywords and concepts | Glycemic control and coronary heart disease risk in persons with and without diabetes: The atherosclerosis risk in communities study. Arch Intern Med 2005 Sep 12; l65(l6):1910-6.
Tapsell LC et al. Including walnuts in a low-fat/modified-fat diet improves HDL cholesterol-to-total cholesterol ratios in patients with type 2 diabetes. Diabetes Care 2004; 27:2777'-83.
Trouillas P. The "making" of a parenchymal hematoma. An early coagulopathy and specific risk factors contribute to grave intracerebral bleeding after intravenous rtPA thrombolysis. | Tori Hudson, N.D. See book keywords and concepts | There are heart disease risk factors unique to women. These include oral contraceptive use, pregnancy, having had both ovaries removed, and premature menopause. Additional risk factors not related to gender include increased body fat, especially if it is in the abdominal area; history of smoking; being sedentary; diabetes mellitus; high blood pressure; poor lipid ratios; and family history.
OVERVIEW OF ALTERNATIVE TREATMENTS
Conventional and alternative medicine practitioners agree that, in most cases, atherosclerosis and cardiovascular disease are directly related to diet and lifestyle. | Bottom Line Health See book keywords and concepts | | STUDY FINDINGS
The University of Maryland Medical School study of more than 15,000 adults found that elevated blood levels of CRP are closely connected with traditional heart disease risk factors, such as obesity, smoking, high blood pressure and elevated cholesterol. Elevated CRP levels rarely occur in the absence of these traditional risk factors, the researchers say.
The CRP test turned out to be one of the greatest myths in cardiovascular medicine.
Michael Miller, MD
"We believe that high C-reactive protein is truly related to the company it keeps," says principal investigator Dr. | Ann M. Coulston and Carol J. Boushey See book keywords and concepts | Antioxidant vitamins and coronary heart disease risk: A pooled analysis of 9 cohorts. Am. J. Clin. Nutr. 80, 1508-1520.
273. Virtamo, J., Rapola, J. M., Ripatti, S., et al. (1998). Effect of vitamin E and beta carotene on the incidence of primary nonfatal myocardial infarction and fatal coronary heart disease. Arch. Intern. Med. 158, 668-675.
274. Bjelakovic, G, Nikolova, D., Gluud, L. L., Simonetti, R. G, and Gluud, C. (2007). Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis. JAMA 297, 842-857.
275. | Elaine Magee See book keywords and concepts | There is also some evidence that plant omega-3s lower heart disease risk in their own right.
___ _y to offer a measure of protection against some cancers, but so do omega-3s —again through different mechanisms.
Even more interesting, these two components appear to work better together in fighting some diseases than alone. Recent lab studies indicated that the combination of a specific lignan known as SDG and the omega-3-rich oil in flaxseed was more effective in reducing the spread of established tumors than either was alone. | | Therefore, if we are going to study the way diet influences heart disease risk, a good place to start is by evaluating how what we eat raises or lowers LDL and triglyceride levels. In addition to losing weight if you're heavy and increasing physical activity, you can lower LDL levels with some dietary changes.
Limit saturated and trans fats. Saturated fats, which we just discussed, are easy to identify because they're solid at room temperature (think butter). Trans fats, a once popular additive in many packaged foods, may be even worse for you than saturated fats. | | The reduction in heart disease risk, though, has been much more impressive. For somewhat modest increases of nut consumption (up to 20 grams a day or a few tablespoons, depending on the nut in question), the reduction in risk has been around 18 to 48 percent.
THE FAB FOUR FOODS IN THE PORTFOLIO PLAN
In addition to eating 5 to 10 serving of fruits and vegetables a day, as well as more plant protein (like beans), the Portfolio plan involves getting the following foods into your diet every day.
1. | Tori Hudson, N.D. See book keywords and concepts | Estrogen has favorable effects on several heart disease risk factors: HRT increases high-density lipoprotein (HDL) cholesterol, decreases low-density lipoprotein (LDL) cholesterol, reduces oxidation of LDL cholesterol, lowers uptake of LDL in blood vessels, binds to vascular estrogen receptors, reduces vascular tone, preserves endothelial function, increases prostacyclin release, decreases thromboxane A2 formation, decreases fibrinogen, reduces plasminogen activator inhibitor, and decreases fasting blood glucose and insulin. | Elaine Magee See book keywords and concepts | Plus, they can lower heart disease risk if they replace saturated or trans fats in the diet. But when eaten in excess, they can cause trouble.
SATURATED FATS
Saturated fats are fatty acids that have the maximum number of hydrogen atoms attached to every carbon atom—they are "saturated" with hydrogen. Some saturated fats (like butter or lard) are solid at room temperature, while others (whole milk or cream) are suspended in liquid. | Joe Graedon, M.S. and Teresa Graedon, Ph.D. See book keywords and concepts | Conventional wisdom would predict that the low-fat Dean Ornish diet would beat every other diet hands down on the heart disease risk score. Au contraire. All of these diets were roughly comparable in helping people lose weight.433 Many cardiologists were shocked to learn, however, that those following a high-protein, low-carbohydrate regimen ended up with a better score on heart disease risk factors than those following an Ornish-type low-fat, high-carbohydrate diet. That is because the higher-fat diets raised good HDL cholesterol more than the Ornish approach. | Ann M. Coulston and Carol J. Boushey See book keywords and concepts | The impact of lowering major coronary heart disease risk factors has been reported in a recent analysis demonstrating that approximately one-half of the decrease in CHD in the United States between 1980 and 2000 can be attributed to reductions in total cholesterol, blood pressure, and body mass index (BMI) [1]. The reduction in these major risk factors is due to lifestyle and behavioral interventions, as well as pharmacotherapy. Thus, diet can have a significant impact on CVD risk factors, and, consequently, healthy diet and lifestyle practices can markedly decrease the risk for CHD. | Lester A. Mitscher and Victoria Toews See book keywords and concepts | In fact, flavonoid intake accounted for about 25 percent of the difference in heart disease risk in the groups of men.5
The heart is not the only part of the body to benefit from flavonoids. Another study conducted by Dutch researchers, called the Zutphen Study, found that flavonoids also protect the blood vessels. Dr. Sirving O. Keli followed the diets of 552 middle-aged men for up to fifteen years while tracking their incidence of stroke. The men with the highest intake of flavonoids had 73 percent fewer strokes than the men with a low intake of flavonoids. | Ann M. Coulston and Carol J. Boushey See book keywords and concepts | Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: A randomized trial. JAMA 293, 43-53.
176. Foster, G. D., Wyatt, H. R., Hill, J. O., et al. (2003). A randomized trial of a low-carbohydrate diet for obesity. N. Engl. J. Med. 348, 2082-2090.
177. Gately, P. J., King, N. A., Greatwood, H. C, et al. (2007). Does a high-protein diet improve weight loss in overweight and obese children? Obesity 15, 1527-1534.
178. Meckling, K. A., Gauthier, M., Grubb, R., and Sanford, J. (2002). | Elaine Magee See book keywords and concepts | Here's the fact that got my attention, though: In virtually all studies that examined the impact of nuts in our diet, nut consumption has been associated with a reduction in coronary heart disease risk.
Each nut contains its own unique profile of phytochemicals, types of fatty acids, and types and amounts of fiber. It's no accident that the Portfolio study chose to use almonds.
Almonds may improve cholesterol levels. Almonds (and most nuts) contain large amounts of oleic acid (a monounsaturated fatty acid), which may help raise HDL cholesterol and possibly lower LDL cholesterol. | Ann M. Coulston and Carol J. Boushey See book keywords and concepts | Association between coronary heart disease risk factors and physical fitness in healthy adult women. Circulation 67, 977-983.
44. Hovell, M., Sallis, J., Hofstetter, R., Barrington, E., Hackley, M., Elder, J., Castro, F., and Kilbourne, K. (1991). Identification of correlates of physical activity among Latino adults. J. Community Health 16, 23-36.
45. King, A. C, and Tribble, D. L. (1991). The role of exercise in weight regulation in nonathletes. Sports Med. 11, 331-349.
46. Slattery, M. L., McDonald, A., Bild, D. E., Caan, B. J., Hilner, J. E., and Jacobs, D. R., Jr. and Liu, K. (1992). | | Heart disease risk factors, diabetes, and prostatic cancer in an adult community. Am. J. Epidemiol. 129, 511-517.
182. Nilsen, T. I., and Vatten, L. J. (1999). Anthropometry and prostate cancer risk: A prospective study of 22,248 Norwegian men. Cancer Causes Control 10, 269-275.
183. Boland, L. L., Mink, P. J., Bushhouse, S. A., and Folsom, A. R. (2003). Weight and length at birth and risk of early-onset prostate cancer (United States). Cancer Causes Control 14, 335-338.
184. Friedenreich, C. M., McGregor, S. E., Courneya, K. S., Angyalfi, S. J., and Elliott, F. G. (2004). | Hyla Cass See book keywords and concepts | Actually, research shows that the antioxidant, blood-thinning effect of CoQjo in supplement form plus a statin reduce heart disease risk better than the drug alone. Starting both the CoQ10 supplement and the statin together can prevent depletion entirely.
Supplementing CoQ10 is easy and safe. It's non-toxic even at high doses. Possible, but uncommon, side effects may include mild inability to sleep, elevated liver enzyme levels, rashes, nausea, and upper abdominal pain.
Dose: If you take statins, take 100-300 mg per day of this nutrient. | | DRUGS FOR heart disease risk FACTORS AND THE NUTRIENTS THEY DEPLETE
All this having been said, you may, in the short or long term, benefit from statins if:
1. You are diabetic.
2. You have had a heart attack.
3. You've been diagnosed with heart disease but have not had a heart attack.
If your blood pressure is high or borderline, keeping it down with drugs may be necessary as well. High blood pressure is dangerous and does damage to artery walls.
Both types of drugs deplete nutrients, which must be replenished, as you'll see next. | | There is no relationship between blood cholesterol and heart disease risk in women over fifty or in men over seventy. Statins given to these individuals are not only wasted, but expose them to risk of side effects that isn't outweighed by benefit to their hearts.
?A survey of South Carolina adults found no correlation of blood cholesterol levels with "bad" dietary habits, such as use of red meat, animal fats, fried foods, butter, eggs, whole milk, bacon, sausage, and cheese. Does that sound like heresy, or what?
? | | High cholesterol counts are indicative of increased heart disease risk, but it appears that we've been looking at the equation backwards: high blood fats are an effect, not a cause, of elevated cardiovascular risk. And the evidence strongly suggests that high cholesterol is a result of excess inflammation in the body. That excess inflammation seems to be a more likely root cause of dangerous changes in the cardiovascular system. | | Since this discovery, many of the older NSAIDS have been implicated in raising heart disease risk as well. This means tough choices for people who need help with arthritis pain or other kinds of muscle or joint pain.
WHAT IS ARTHRITIS?
The word arthritis means "inflammation of the joints" and can include several types. Osteoarthritis (OA) is the most common—the kind of arthritis that often afflicts people in the knees, fingers, hips, or back as they age or because of wear and tear. | Steven V. Joyal See book keywords and concepts | The triglyceride/HDL ratio is a revealing predictor of heart disease risk that is often underutilized. The lower your triglyceride level or the higher your HDL level, the smaller your ratio will be. People who have a high ratio of triglycerides to HDL cholesterol are at high risk of insulin resistance.
The dietary and other lifestyle guidelines discussed in chapters 5 through 10 of this book can help you achieve healthy triglyceride and/or cholesterol levels. | Ann M. Coulston and Carol J. Boushey See book keywords and concepts | Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. JAMA 293, 43-53.
60. Gardner, C. D., Kiazand, A, Alhassan, S., Kim, S., Stafford, R. S., Balise, R. R, Kraemer, H. C, and King, A. C. (2007). Comparison of the Atkins, Zone, Ornish and LEARN diet for change in weight and related risk factors among overweight premenopausal women. JAMA 297, 969-977'.
61. Arterburn, D. (2006). The BBC diet trials: reality television and academic researchers jointly tackle the weight loss industry. BMJ 332, 1284-1285.
62. | Elaine Magee See book keywords and concepts | The Mediterranean diet, independent of any other factor, reduces levels of inflammation related to heart disease risk," says lead researcher Demosthenes Panagiota-kos, PhD. He and his colleagues showed that the more closely participants' eating habits matched the Mediterranean diet (2,200 men and women, ages 18 to 89), the lower their levels of C-reactive protein, a marker of general inflammation in the bloodstream.
Lower the risk of Alzheimer's. | Michael T. Murray See book keywords and concepts | Note: Don't confuse C-peptide with C-reactive protein—an indicator of systemic inflammation and a marker for heart disease risk.
Figure 6.1. C-Peptide Is Removed from Proinsulin to Make Active Insulin
C-PEPTIDE RESULTS
INTERPRETATION
Normal
The insulin production is at normal level
Less than normal
A. Newly diagnosed type 1 diabetic
B. Chronic, long-term type 2 diabetic
Greater than normal
A. Newly diagnosed type 2 diabetic
B. A benign tumor of the pancreas, insulinoma (rare).
Undetectable
A. Chronic type 1 diabetic
B. Postsurgical removal of pancreas
(rare). |
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